Antigen Presentation To Human T Lymphocytes. Ii

1. Human T Shirt Company

To understand the diversity among human leukocyte antigens (hla) or major histo-compatibility complex (mhc) to know the role of hla antigens in transplant Major Histocompatibility Complex (MHC). Department of microbiology. Study PHD Lecture 11 -- Human Leukocyte Antigen Flashcards at ProProfs - Related Flashcards immunology 11 – Lymphocyte= Antigen Recognition and Response to Antigen.

Human T Shirt Company

Abstract Human CD4 (^+ ) T cells process and present functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains unknown. We eluted and sequenced HLA-DR-bound self-peptides presented by CD4 (^+ ) T cells in order to compare the T cell-derived peptide repertoire to sequences derived from genetically identical B cells. We identified several novel epitopes derived from the T cell-specific proteome, including fragments of CD4 and IL-2. While these data confirm that T cells can present peptides derived from the T-cell specific proteome, the vast majority of peptides sequenced after elution from MHC were derived from the common proteome. From this pool, we identified several identical peptide epitopes in the T and B cell repertoire derived from common endogenous proteins as well as novel endogenous epitopes with promiscuous binding. These findings indicate that the endogenous HLA-DR-bound peptide repertoire, regardless of APC type and across MHC isotype, is largely derived from the same pool of self-protein.